SynAct Pharma Initiates Phase II Study with AP1189 for the Treatment of ARDS in COVID-19 Patients. SynAct Pharma "SynAct's primary focus is to rapidly determine the safety and efficacy of AP1189 as a potential treatment for COVID-19.

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AP1189 is developed as an add-on to MTX to reduce inflammation and support resolution ➜attenuate symptoms and decrease time to resolution ➜reduce need for second line treatment and/or reduce MTX dose 12 AP1189 SynAct Pharma AB ("SynAct") today announced that dosing in the second part of the exploratory clinical Phase 2 study with AP1189 in Covid-19 patients conducted under the RESOVIR collaboration has been initiated following completion of the initial open label part of study. The second part is a randomized double-blind placebo-controlled study in 56 Covid-19 patients at clinical sites at The AP1189 compound is a biased melanocortin receptor agonist developed for once daily oral dosing and is currently tested in Phase 2 clinical trials in Rheumatoid Arthritis and Nephrotic Syndrome.

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SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS). The patients will be enrolled at medical centers in Brazil and in a collaboration between SynAct Pharma, Queen Mary I am indeed happy that we have started the second phase of the study to investigate whether AP1189 can promote inflammatory resolution and thereby reduce time to recovery and reduce the risk of development of severe ARDS,” said primary investigator Prof.

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"We have recently had good progress in the study in patients with Rheumatoid Arthritis where the compound is tested in treatment naïve patients with severe active disease as an add on to Anläggningen planeras bli en del av Saabs globala leveranskedja till de civila flyg- och försvarsmarknaderna, förklarar Mikael Franzén, chef för affärsenheten Gripen Brazil, Saab Aeronautics.